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kernel for multi-socket systems?

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Is there a preferred kernel for multi-socket systems, such as Opteron systems, or is the default "desktop" kernel the best.
Basically, I'm running large climate models - so heavy numerics and very long runtimes. Is the support for Opterons the
same in OS12.3 and OS13.1? (I would also consider installing a different distro of Linux if there were an advantage, but
I think all the distros have similar kernels...)
SuperMicro 2U server
Opteron 6386SE
512GB memory
OS 12.3
Thank you!!!!! :)

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